MAO – B Inhibitor “Selegiline” Attenuates Oxidative Stress and Arthritic Parameters in an Invitro Repurposed Studies

Abstract

The immune system damages bones and joint cartilage in rheumatoid arthritis (RA), a chronic form of inflammatory disease that lowers quality of life. Few studies have investigated the potential role of oxidative stress markers in the pathophysiology of RA disease development and the positive impact of antioxidants. This study aims to evaluate the Antiarthritic poteitial of MAO- B inhibitor “Selegiline” including its capability to curtail the oxidative stress by scavenging the free radicals. Different inviro antioxidant assays and antiarthritic assays was performed to conduct this study. Selegiline presents a concentration dependent inhibition in all the invitro antioxidant assays such as DPPH, ABTS, NO, H2O2, Superoxide, Hydroxyl, Peroxynitrite radical as well as in invitro antiarthritic assays while evaluating all these in the concentration range of 25 µg/ml to 250 µg/ml. The consequences of these results manifest that Selegiline is quite effective enough to decrease the inflammatory parameters and also reducing in free radical induced oxidative stress. Therefore this study unlocks the opportunity of conducting further research on repositioning of Selegiline in the management of Rheumatoid Arthritis in terms of different invivo and exvivo model